Carina Biotech
Carina Biotech is an Australian immuno-oncology company developing CAR-T and other adoptive cell therapies for the treatment of solid cancers. In addition to its LGR5-targeted CAR-T cell therapy CNA3103 for…
Overview
Carina Biotech is an Australian immuno-oncology company developing CAR-T and other adoptive cell therapies for the treatment of solid cancers.
In addition to its LGR5-targeted CAR-T cell therapy CNA3103 for advanced colorectal cancer, Carina has a deep pipeline of CAR-T programs as well as platform technologies for the positioning of CAR-T cells within solid tumours, to enhance potency and induce “serial” killing that is capable of memory.
The company has a pipeline of novel CAR-T programs in preclinical development for the treatment of a range of solid cancers, with the lead program targeting LGR5, a cancer stem cell marker.
In addition, the company has developed a proprietary multi-functional chemokine receptor platform to enable CAR-T cell arming, homing and access to tumours and an efficient CAR-T cell manufacturing platform to increase efficacy and persistence within tumours.
Using its proprietary chemokine receptor platform, Carina aims to improve access to and infiltration of solid cancers by CAR-containing cells, resulting in more potent and specific cancer killing and reduced off-target effects.
Carina also has a fully integrated, proprietary manufacturing process that has both a proprietary 5-day manufacturing process and improved CAR-T cell quality, capable of delivering robust “serial-killing” CAR-T cells to patients.
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